Physiological Consequences of Brain Insulin Action

The  brain is crucial for the regulation of whole-body metabolism and  behavior. The pancreas-derived hormone insulin modulates brain function  and affects energy metabolism as well as cognition. This is partially  achieved by modulating several types of brain cell populations including  those relevant to satiety and reward. Importantly, brains of  Alzheimer´s disease patients exhibit a signature of brain insulin  resistance with perturbed brain metabolism. This book will cover the  basics of insulin signaling in the brain and will describe concepts of  insulin resistance, a feature of type 2 diabetes. Moreover insulin´s  effect on cognitive function will be pointed out and the association  between brain insulin resistance and neurodegenerative diseases  discussed. Additionally, potential behavioral and pharmacological  concepts which can affect brain insulin signaling will be summarized.

Key Features:

• Summarizes insulin and the closely related IGF-1 receptor signaling 
• Depicts concepts of insulin resistance 
• Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior
• Describes potential behavioral and pharmacological approaches to support brain insulin signaling