Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics

Explore the past, present, and future of cancer cytogenetics

In  Abnormal Chromosomes: The Past, Present, and Future of Cancer  Cytogenetics, globally renowned researchers Drs. Sverre Heim and Felix  Mitelman deliver a state-of-the-art review of how cancer cytogenetic  analyses have contributed to an improved understanding of tumorigenesis  as well as to the diagnosis and treatment of cancer patients. The book  also discusses how cytogenetics – the study of chromosomes - meets,  interacts with, and cross-fertilizes other investigative technologies,  including molecular somatic cell genetics.

The book provides an  impetus to think more deeply about the role chromosomes, and their  abnormalities, play in health and disease, especially in neoplastic  disorders. From which origins did cytogenetics develop? How did the  finding of acquired chromosomal abnormalities in cells of leukemias and  solid tumors influence our understanding of cancer as a biological  process? How was information of this nature put to good use in the  clinical management of cancer patients?

Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics offers readers:
 A thorough introduction to ancient theories of disease, the advent of  cellular pathology, and how a scientific interest in chromosomes  developedComprehensive exploration of the conceptual importance of  Theodor Boveri and his somatic mutation theory of cancerA detailed  chronological resume of cancer cytogenetic discoveries during the 20th  centuryIn-depth discussions of the role of chromosome abnormalities,  oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid  tumors, together with a survey of what chromosome analyses have  revealed about the clonal evolution of neoplastic cell populationsA  discussion of the importance of pathogenetic classifications of  neoplastic diseases, the role chromosome abnormalities play in this  context, and which technological breakthroughs can be expected in  chromosome-oriented cancer researchAbnormal Chromosomes: The Past,  Present, and Future of Cancer Cytogenetics was written for everyone with  a scientific or clinical interest in cancer, especially how acquired  chromosome abnormalities lead to neoplastic transformation. The book  teaches how cytogenetic analyses contribute to a better understanding of  tumorigenesis, but also how the finding of specific chromosome  aberrations can be crucial for the diagnosis, prognosis, and management  of cancer patients.